That hasn’t been the case for decades. Israel has a lot of allies in the region (basically the entire anti-Iran coalition). Admitadly, these alliances are largely premised on Israel’s military and intelligence might, which would be diminished without US support; but Israel still has significant in-house capabilities.
As to the actual power dynamics, I agree that the US has a lot of leverage. But that is meaningless if they don’t use it. Moreso now that Israel knows they would only need to wait for the next administration to reverse course if we started using our leverage now.
Leaders say a lot of things. Even without nukes, Israel has enough conventional military might to have a significant detergent effect (and to defend against attacks that actually do happen).
Further, the politics in the middle east has not been Arabs vs Israel for decades. Israel is a well positioned member of the anti Iran coalition.