Having pushed Earth to the brink of environmental disaster and overpopulation, the central government segregates the populace. The wealthy and well-connected get to remain as they are, but billions of everyday working folks get forced into artificial, self-contained living spaces over the course of several decades. Some of those spaces remain relatively comfortable. Many are densely populated, and some of the most isolated don’t even get natural sunlight. None of them have any say in how they are governed. This breeds unrest.

In the most remote communities, there is a growing push towards being self-governed. In tandem, the idea that their half-century plus of environmental isolation is pushing a new evolutionary path for humans starts taking hold. The champion of this ideal is a charismatic politician, who uses the notion of a higher-evolved humanity as justification for independence. Amid tensions with the corrupt, complacent central government, the politician dies suddenly. Both movements are then co-opted by populist fascists, whose leading family has effectively complete control of the local military. This leads to the deadliest, most brutal war humanity has ever seen.

This is the setup for Mobile Suit Gundam (1979), and yeah, I’d say that’s still pretty relevant.