2050s for 1st edition, I think current edition is 2070s. Dragons started waking up in the early 2010s though. There has also been significant geopolitical upheaval, especially in the Americas and Europe. The general assumption is that a nuyen being about 1 modern dollar is about the right ballpark.
I do enjoy seeing the ‘oh, this is why’ feeling in people. I got much the same reading Dracula, and I recommend it if you have yet to have the pleasure. You might think you know it, but trust me, give it a go.